{"product_id":"total-synthesis-of-natural-products-with-antimicrobial-activity-von-andrew-giltrap","title":"Total Synthesis of Natural Products with Antimicrobial Activity","description":"\n                                This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the \n                \n                \u003ci\u003ePseudomonas aeruginosa\u003c\/i\u003e\n                                 biofilms that are responsible for significant mortality among cystic fibrosis patients.\n                \n                \u003cbr\u003e\n                            \n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789811342455\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9789811088056\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9789811342455","offer_id":39456307576925,"sku":"9789811342455","price":139.09,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9789811088056","offer_id":1516070207494,"sku":"9789811088056","price":139.09,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/2cbbcab1-b26b-4f02-bcb5-7ebf7af330ff.jpg?v=1778743177","url":"https:\/\/shop.autorenwelt.de\/products\/total-synthesis-of-natural-products-with-antimicrobial-activity-von-andrew-giltrap","provider":"Autorenwelt Shop","version":"1.0","type":"link"}