{"product_id":"tolerance-of-chemotherapy-in-colorectal-cancers-von-sondes-bizid","title":"Tolerance of Chemotherapy in colorectal cancers","description":"\u003cp\u003eTo assess tolerance according to the WHO classification of adjuvant and palliative chemotherapy for colorectal cancer. Methods: Prospective study including 40 patients with colorectal adenocarcinoma treated with chemotherapy over a period of 4 years. Results: Forty patients , mean age 56 years were included. 71 lines of chemotherapy were administered, side effects were noted in 59 lines (83%), severe toxicities were mainly observed with Folfox 4 and Folfiri type chemotherapy. Side effects, all toxicities combined, were more frequently observed with palliative chemotherapy 66% (p=0.04) and with advanced stages (stage IV) 44% (p=0.04). After symptomatic treatment, the improvement of symptoms was noted in 52.5% of cases. Worsening of symptoms was noted in 42.5% leading to dose reduction in 76% of cases with secondary improvement in 63% of cases. Monitoring by the WHO sheet had made it possible to avoid changing or stopping the therapeutic line in ¿ of the cases. Indeed, a change of line was necessary in 8.6% and a permanent stop in 18.6%.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786205100066\"\u003e\u003ch3\u003eTreatment and prevention\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786205100066","offer_id":40452457398365,"sku":"9786205100066","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/54e506cb-4d78-41e1-9d24-f8147ef865cd.png?v=1758348333","url":"https:\/\/shop.autorenwelt.de\/products\/tolerance-of-chemotherapy-in-colorectal-cancers-von-sondes-bizid","provider":"Autorenwelt Shop","version":"1.0","type":"link"}