{"product_id":"tissue-is-the-issue-endobronchial-ultrasonography-and-ebus-tbna-von-sherif-mohamed","title":"Tissue is the issue: Endobronchial Ultrasonography and EBUS-TBNA","description":"\u003cp\u003eDirect real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) using the convex probe endobronchial ultrasound (CP-EBUS) is a relatively new minimally-invasive and accurate technique for preoperative staging of NSCLC patients. Tissues obtained by EBUS-TBNA allow further analyses to be carried out and may help directing NSCLC patients to molecularely-based different therapies. The objective for this work was to investigate the feasibility of EBUS-TBNA for obtaining nodal tissue samples that can be utilized for IHC analysis. Patients with pN2-NSCLC were enrolled. Mediastinal LN specimens obtained by EBUS-TBNA in those patients underwent IHC staining for the expression of 6 cell cycle-related proteins (pRb, cyclin D1, p16, p53, p21, and Ki-67). Results revealed that immunohistochemical staining was feasible in all mediastinal nodal tissue samples. All the examined cases showed an abnormal expression of at least one of the studied 6 cell cycle proteins. In conclusion, EBUS-TBNA is an effective tool, not only for staging of LC, but also for obtaining mediastinal nodal tissue samples amenable for further evaluation.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786139902637\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786139902637","offer_id":39446836510813,"sku":"9786139902637","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a13e6e56-8d3b-4bfc-bd2b-82b0c1ed2a59.jpg?v=1770792130","url":"https:\/\/shop.autorenwelt.de\/products\/tissue-is-the-issue-endobronchial-ultrasonography-and-ebus-tbna-von-sherif-mohamed","provider":"Autorenwelt Shop","version":"1.0","type":"link"}