{"product_id":"tia-1-and-herpes-simplex-virus-type-1-an-interaction-the-influence-of-tia-1-on-hsv-1-replication-von-william-stewart","title":"TIA-1 and Herpes Simplex Virus Type 1: An Interaction","description":"\u003cp\u003eDuring the process of protein translation,  phosphorylation of eIF2-alpha prevents its binding  to the preinitiation complex and hence the process  of translation. The RNA binding protein, TIA-1, then  directs these complexes to molecular storage depots  known as stress granules. The replication of HSV-1, containing different  variants of the ICP34.5 gene and those without the  ICP34.5 gene were compared in diploid fibroblasts  obtained from normal mice, those lacking TIA-1 and  reconstituted with TIA-1. This research showed that  HSV-1 replicates better in cells that lack  TIA-1. The extent of viral replication was strain  dependent. This shows that the cell has a method for  preventing viral replication.  The functions of TIA-1 include the formation of  stress granules in cells which undergo abortive  protein translation and cytokine modulation. This  study explores the possibility of interaction of the  cellular protein, TIA-1 at the viral replication  level. The possibility may be that TIA-1 affects, in  a strain dependent manner, replication of HSV-1. A  potential mechanism for antiviral properties of the  cellular protein TIA-1 is be discussed.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639088427\"\u003e\u003ch3\u003eThe Influence of TIA-1 on HSV-1 Replication\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783639088427","offer_id":39439720120413,"sku":"9783639088427","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4f26b54d-c346-46bf-938f-33ae5c7190ae.jpg?v=1774758230","url":"https:\/\/shop.autorenwelt.de\/products\/tia-1-and-herpes-simplex-virus-type-1-an-interaction-the-influence-of-tia-1-on-hsv-1-replication-von-william-stewart","provider":"Autorenwelt Shop","version":"1.0","type":"link"}