{"product_id":"the-uptake-and-depletion-of-tocopherols-von-rong-gao","title":"THE UPTAKE AND DEPLETION OF TOCOPHEROLS","description":"\u003cp\u003eAs an important chain-breaking antioxidant, the role of Vitamin E has attracted attentions from all over the world.  Alpha-Tocopherol and gamma-tocopherol are two of the eight different forms of vitamin E.  The dietary intake of gamma-tocopherol is generally higher than that of alpha-tocopherol.  However, the levels of alpha-tocopherol in human blood have consistently been shown to be higher than those of gamma-tocopherol.  This could be due, in part, to a differential cellular uptake of the two tocopherol forms.  We sought to resolve this question by studying the uptake and depletion of both alpha-tocopherol and gamma-tocopherol in RAW 264.7 macrophages.  The results indicate that a faster uptake and depletion of gamma-tocopherol compared with alpha-tocopherol.  The presence of gamma-tocopherol can promote the uptake of alpha-tocopherol by macrophages.  The metabolism of alpha-tocopherol was faster than gamma-tocopherol. These results implied the existence of a hypothetical transport protein, which can preferentially select gamma-tocopherol over alpha-tocopherol.  The affinity of this transport protein for alpha-tocopherol could be increased by the presence of gamma-tocopherol.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843374125\"\u003e\u003ch3\u003eTHE UPTAKE AND DEPLETION OF TOCOPHEROLS IN RAW 264.7 MACROPHAGES\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843374125","offer_id":39497106849885,"sku":"9783843374125","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/261ac890-26cd-4803-bccc-2983e3e02acd.jpg?v=1758345909","url":"https:\/\/shop.autorenwelt.de\/products\/the-uptake-and-depletion-of-tocopherols-von-rong-gao","provider":"Autorenwelt Shop","version":"1.0","type":"link"}