{"product_id":"the-role-of-xbp-1-in-colorectal-cancer-metastasis-von-ayed-abushbak","title":"The Role of XBP-1 in Colorectal Cancer Metastasis","description":"\u003cp\u003eThe author studied the role of X-Binding Protein (XBP-1) in CRC metastasis. Results indicated that, XBP-1 was expressed at high levels in metastatic and poorly differentiated tissue sample and a relatively low levels in moderately and well differentiated tissue samples. Moreover, XBP-1 was expressed in all cell lines of CRC examined in this study. Overexpression of XBP-1 in SW480 cells promoted the invasion of cells, and this increase in tumor cell invasion was inhibited by inhibition of XBP-1 using small interfering RNA molecules (siRNA). In addition, results indicated that overexpression of XBP-1 in SW480 cells induced the level of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) and inhibition of XBP-1 significantly decreased expression of VEGFR2, showing that XBP-1 is working upstream of VEGF-R2. This study demonstrated that pretreatment of HCT116 cells with ER stress inducers such as Tunicamycin (TM) decreased 5-FU-induced-apoptosis. The results are strongly suggesting that XBP-1 promoted the invasion of colorectal cancer both in vitro and in vivo. Overexpression of XBP-1 cells enhanced VEGFR2 levels and could be responsible for CRC cell metastasis.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786139984022\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786139984022","offer_id":39460146020445,"sku":"9786139984022","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/7dc87bf2-7949-4aa9-9bfa-d38f394d2dca.jpg?v=1770789052","url":"https:\/\/shop.autorenwelt.de\/products\/the-role-of-xbp-1-in-colorectal-cancer-metastasis-von-ayed-abushbak","provider":"Autorenwelt Shop","version":"1.0","type":"link"}