{"product_id":"the-role-of-p300-dependent-myc-acetylation-in-myc-functions-von-marina-vorontchikhina","title":"The Role of P300-Dependent MYC Acetylation in MYC Functions","description":"\u003cp\u003eI demonstrate that HAT p300 acetylates MYC preferentially at K157\/158 in transfected mammalian cells. I also show that MYC overexpression increases the level of endogenous p300. Moreover, our data provides a potential link between MYC acetylation and its biological functions. I found that MYC acetylation at lysine 158 reduces MYC-activated apoptosis and this could be via transcriptional regulation of pro-apoptotic Nrf1 and Cytochrome c (Cyc) genes. These findings might be important for prospective drug development against MYC-dependent tumors. New therapeutics which drive transformed cells to apoptosis via prevention of MYC acetylation at K157\/158 by p300 could be beneficial for the treatment of MYC-dependent cancers.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659809163\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659809163","offer_id":39449534365789,"sku":"9783659809163","price":71.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5a341cde-b87d-46b5-81be-3e3f24b481cc.jpg?v=1774935085","url":"https:\/\/shop.autorenwelt.de\/products\/the-role-of-p300-dependent-myc-acetylation-in-myc-functions-von-marina-vorontchikhina","provider":"Autorenwelt Shop","version":"1.0","type":"link"}