{"product_id":"the-role-of-egfr-in-c-fos-dependent-osteosarcoma-formation-von-parastoo-shahrouzi","title":"The role of EGFR in c-fos-dependent osteosarcoma formation","description":"\u003cp\u003eOsteosarcoma is the most common type of bone cancer. Although stage I osteosarcoma has a promising prognosis, stage III osteosarcoma with lung metastases with only about 30% survival rate is worrying. Expression of EGFR and its downstream proteins has been regularly observed in osteosarcoma. In this book, the main focus is on two major aims: 1.Analysis of the role of EGFR signaling during bone tumor formation by breeding H2-c-fosLTR transgenic mice, that develop OS with 100% penetrance, to mice that harbor either reduced (Egfrwa2\/wa2) or elevated (Col1-AREG) EGFR signaling; 2.Analysis of the effect of EGFR inhibition on proliferation, viability and apoptosis as well as on EGFR downstream signaling proteins in c fos transgenic osteosarcoma cells.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202213479\"\u003e\u003ch3\u003eAn insight into the cell signaling network in osteosarcoma\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786202213479","offer_id":40150092677213,"sku":"9786202213479","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9470c9be-b6ef-41a9-9fa8-4c0b77a5819c.jpg?v=1773386200","url":"https:\/\/shop.autorenwelt.de\/products\/the-role-of-egfr-in-c-fos-dependent-osteosarcoma-formation-von-parastoo-shahrouzi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}