{"product_id":"the-role-of-cytokines-on-synaptic-plasticity-in-the-dentate-gyrus-von-derval-cumiskey","title":"the role of cytokines on synaptic plasticity in the dentate gyrus","description":"\u003cp\u003ePro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer¿s disease. Tumour necrosis factor-¿ (TNF-¿) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF-¿ and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF-¿ and IL-18 can impair LTP in the dentate gyrus.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844319941\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844319941","offer_id":39495971307613,"sku":"9783844319941","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e6474baf-d642-448c-ac12-c52a1844002a.jpg?v=1782451319","url":"https:\/\/shop.autorenwelt.de\/products\/the-role-of-cytokines-on-synaptic-plasticity-in-the-dentate-gyrus-von-derval-cumiskey","provider":"Autorenwelt Shop","version":"1.0","type":"link"}