{"product_id":"the-role-of-autophagy-in-degenerative-diseases-von-joseph-kariuki","title":"The Role of Autophagy in Degenerative Diseases","description":"\u003cp\u003eAkademische Arbeit aus dem Jahr 2020 im Fachbereich Medizin - Sonstiges, , Sprache: Deutsch, Abstract: Autophagy is a well-developed intracellular breakdown mechanism. Based on the mechanism of cargo transport into lysosomes used by mammals, there are three types of autophagic processes: chaperone-mediated autophagy, microautophagy, and macroautophagy, all of which are referred to as autophagy. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAutophagosomes are double-membrane-bound vesicles that absorb unnecessary or misfolded proteins as well as damaged subcellular organelles and transport them to lysosomes for disintegration. The mammalian target of rapamycin complex 1 (mTORC1), a critical regulator of autophagy, inhibits autophagy at a low baseline level in almost all cells to maintain cellular homeostasis. When mTORC1 is inhibited, autophagy is released in response to many types of\u003c\/p\u003e\u003cp\u003ecellular stress, such as food restriction, growth factor withdrawal, or hypoxia, and it is greatly increased to meet high energy demands.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eDynamic interactions between compartments of the autophagic and endocytic pathways are essential for digestion to be completed. As the brain ages, neuron interactions become more prone to irregularities. Autophagy-controlling gene alterations have been associated to a wide spectrum of neurodegenerative illnesses in persons of all ages, which is not surprising. Defects in the autophagy system are seen at various stages in late-onset disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, and familial Parkinson's disease, with varying etiology and therapeutic implications.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783346606341\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783346606341","offer_id":39991976263773,"sku":"9783346606341","price":17.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/50ee3111-b111-41da-b781-c19eaae15f6c.jpg?v=1778128202","url":"https:\/\/shop.autorenwelt.de\/products\/the-role-of-autophagy-in-degenerative-diseases-von-joseph-kariuki","provider":"Autorenwelt Shop","version":"1.0","type":"link"}