{"product_id":"the-polymerase-chain-reaction-von-francois-ferre-richard-a-gibbs-kary-b-mullis-hrsg","title":"The Polymerase Chain Reaction","description":"James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. \"It has not escaped our notice,\" Francis wrote, \"that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material.\" By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act \". . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before\" and, moreover, \" ...\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9780817637507\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9780817637507","offer_id":39415724441693,"sku":"9780817637507","price":74.89,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5d529e32-d406-4516-8f87-757bd88866fe.jpg?v=1781237490","url":"https:\/\/shop.autorenwelt.de\/products\/the-polymerase-chain-reaction-von-francois-ferre-richard-a-gibbs-kary-b-mullis-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}