{"product_id":"the-metabolic-effects-of-echinochrome-pigment-extracted-from-sea-urchin-on-diabetic-rats-von-ayman-mohamed","title":"The Metabolic Effects of Echinochrome Pigment Extracted from Sea Urchin on Diabetic Rats","description":"\u003cp\u003eDoctoral Thesis \/ Dissertation from the year 2018 in the subject Biology - Zoology, grade: 4, Cairo University (Faculty of Science), language: English, abstract: Diabetes mellitus is one of the most public metabolic disorders. It is mainly classified into type 1 and type 2. Echinochrome (Ech) is a pigment from sea urchins that has antioxidant, anti-microbial, anti-inflammatory and chelating abilities. The present study aimed to investigate the anti-diabetic mechanisms of Ech pigment in\u003c\/p\u003e\u003cp\u003estreptozotocin-induced diabetic rats. Thirty-six male Wistar albino rats were divided into two main groups (18 rats\/group). Each group was divided into 3 subgroups (6 rats\/subgroup); control, diabetic and Ech subgroups. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eDiabetic models were induced by a single dose of streptozotocin (60 mg\/kg, i.p) for type 1 diabetes and by a high fat diet for 4 weeks before the injection of streptozotocin (30 mg\/kg, i.p) for type 2 diabetes. Diabetic groups were treated orally with Ech (1 mg\/kg body weight in 10% DMSO) daily for 4 weeks. Ech groups showed a reduction in the concentrations of glucose, globulins, triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), creatinine, urea, uric acid, malondialdehyde (MDA) and the activities of\u003c\/p\u003e\u003cp\u003earginase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT). \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eWhile, it caused general increase in the levels of insulin, total bilirubin (TB), direct bilirubin (DB), indirect bilirubin (IB), total protein (TP), albumin, nitric oxide (NO) and the activities of glucose-6-phosphate dehydrogenase (G6PD), hexokinase, glutathione-S-transferase (GST), superoxide dismutase (SOD) and glutathione reduced (GSH). The histopathological investigation showed partial restoration of pancreatic islet cells and clear improvement in the hepatic and kidney architecture. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe results of this study clearly show that Ech has anti-diabetic potential in both types of diabetes. The possible anti-diabetic mechanisms of Ech involving improved glucose metabolism, restoration of ¿ cells, improve insulin secretion, improve insulin signaling and antioxidant activity.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783668612969\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783668612969","offer_id":39432869707869,"sku":"9783668612969","price":52.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/646c17c2-0974-45ea-ad3c-10ebae558b75.jpg?v=1778473961","url":"https:\/\/shop.autorenwelt.de\/products\/the-metabolic-effects-of-echinochrome-pigment-extracted-from-sea-urchin-on-diabetic-rats-von-ayman-mohamed","provider":"Autorenwelt Shop","version":"1.0","type":"link"}