{"product_id":"the-merozoite-surface-protein-1-of-plasmodium-falcipurum-von-zeleke-mekonnen","title":"The Merozoite Surface Protein 1 of Plasmodium falcipurum","description":"\u003cp\u003eBinding of merozoite proteins to erythrocyte during invasion is a critical step. However, little is known about interactions occurring during merozoite invasion of erythrocytes or complex formation of merozoite surface proteins among themselves.One such important merozoite proteins thought to play a crucial role during invasion of RBCs is Merozoite surface protein 1 (MSP-1), a potential candidate for blood stage vaccine development. In this work, an in vitro interaction assay of MSP-1 with human erythrocytes is described to investigate which subunit of MSP-1 bind to Erythrocytes. Although the specificity of the binding is not clear, our data indicates p38 and p42 appears to interact with erythrocytes. Taken together our data suggest that MSP-1 by itself might not be an initial interaction partner for erythrocytes. Interestingly, our data from association study between MSP-1 and MSP-6 performed in this work clearly indicate that hMSP-6 interacts with MSP-1 complexes as long as p38 is present making this subunit the most important interaction partner. Moreover, we also fine map a stretch of 51 amino acids in MSP-6 responsible for the interaction with MSP-1.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844314571\"\u003e\u003ch3\u003eInteraction with the Surface of Human Erythrocytes and with Surface Proteins MSP-6 and MSP-7\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844314571","offer_id":39871104581725,"sku":"9783844314571","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5f85a20f-95e9-469c-9f9a-13195699f208.jpg?v=1769667907","url":"https:\/\/shop.autorenwelt.de\/products\/the-merozoite-surface-protein-1-of-plasmodium-falcipurum-von-zeleke-mekonnen","provider":"Autorenwelt Shop","version":"1.0","type":"link"}