{"product_id":"the-immune-phenotype-of-mice-deficient-for-ly49q-von-marie-line-goulet","title":"The immune phenotype of mice deficient for Ly49Q","description":"\u003cp\u003ePlasmacytoid dendritic cells are members of the innate immune system and are particularly important in anti-viral immunity since they are the most potent producers of type I interferons. This book describes the phenotype of knockout mice for Ly49Q, a cell surface receptor expressed on pDCs. In vivo, knockout mice with PGK-Neomycin insertion control early murine cytomegalovirus infection better, but no difference could be detected in mice with recombined LoxP sites.  Thus, we observed a differential immune response dependent on the gene knockout strategy.  In mice with PGK-Neomycin insertion, we found enhanced hematopoiesis of some populations of the myeloid lineage and lower activation of pDCs following treatment with particular Toll-like receptor ligands, which translates into diminished T cell stimulatory capacity.  This suggests a role for Ly49Q in regulating hematopoiesis and pDC activation potential.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783845472300\"\u003e\u003ch3\u003eDysregulated hematopoiesis and pDC activation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783845472300","offer_id":39494526271581,"sku":"9783845472300","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a34ce190-1151-469d-ac4b-9cca87fe72c4.jpg?v=1769494770","url":"https:\/\/shop.autorenwelt.de\/products\/the-immune-phenotype-of-mice-deficient-for-ly49q-von-marie-line-goulet","provider":"Autorenwelt Shop","version":"1.0","type":"link"}