{"product_id":"the-effect-of-l-lactate-on-long-term-memory-through-nmda-receptor-von-engy-khamis","title":"The effect of L-lactate on long term memory through NMDA receptor","description":"\u003cp\u003eIn the brain, glycogen, the storage form of glucose, is exclusively localized in astrocytes. Glycogenolysis leads to the production of L-lactate, which is shuttled to neurons for ATP production. Interestingly, L-lactate was recently shown to be not only a source of energy, but also a signaling molecule to neurons. This was demonstrated through the inhibition of L-lactate production or transport in an inhibitory avoidance paradigm, where the rodents developed amnesia. This inhibition of memory consolidation was rescued by L-lactate and not by equicaloric glucose emphasizing that L-lactate acts as a signaling molecule as well. A recent study in our laboratory suggests that the action of L-lactate takes place through a cascade of molecular events via the modulation of N-methyl-D-aspartate receptor (NMDAR) activity. Since NADH produced similar results to those seen with L-lactate, it was hypothesized that the action of the latter is based on altering the redox state of the cell, in particular in view of the fact that redox-sensitive sites are present on the NMDAR. However, the precise molecular mechanism underlying the apparent change in the NMDAR activity is not fully elucidated.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783330322547\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783330322547","offer_id":39428218093661,"sku":"9783330322547","price":64.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/28e2f118-2b02-438b-abc8-e1fc4521444c.jpg?v=1757909467","url":"https:\/\/shop.autorenwelt.de\/products\/the-effect-of-l-lactate-on-long-term-memory-through-nmda-receptor-von-engy-khamis","provider":"Autorenwelt Shop","version":"1.0","type":"link"}