{"product_id":"the-dystrophin-protein-family-von-diana-hazai","title":"The dystrophin protein family","description":"\u003cp\u003eDuchenne muscular dystrophy (DMD)is one of the most  common, severe human disease. Mutations in the DMD  gene are responsible for the disorder. Due to the  mutations, dystrophin proteins are not expressed or  expressed in functionally impaired form. The  dystrophins are members of the dystrophin-associated  protein complex (DAPC)located in the sarcolemma in  the striated muscle. The DAPC links the  extracellular matrix to the actin-based  cytoskeleton and anchors signalling molecules. DAPC  proteins are also  localized in neurons and glia cells within the  central nervous system and they interact with  each other building up different types of DAPCs.  Finding out the localization, colocalization of the  DAPC proteins and the construction of the DAPC  within the brain was the aim of the research and we  also analyzed what kind of changes might occur with  DAPC proteins without dystrophin in dystrophin- deficient mice. There are several DAPC protein  variants located around the capillaries of the brain  which might play a role in the blood-brain barrier.  We supposed that in other organs constituting  barriers,like lung and testis there are also DAPCs.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838396231\"\u003e\u003ch3\u003eLocalization and physiological role\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838396231","offer_id":39469277970525,"sku":"9783838396231","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/ae74c479-6b37-4ff7-881d-a3b31babc7f4.jpg?v=1757825963","url":"https:\/\/shop.autorenwelt.de\/products\/the-dystrophin-protein-family-von-diana-hazai","provider":"Autorenwelt Shop","version":"1.0","type":"link"}