{"product_id":"the-development-of-the-perineum-in-the-human-a-comprehensive-histological-study-with-a-special-reference-to-the-role-of-the-stromal-components-von-s-c-j-van-der-putte","title":"The Development of the Perineum in the Human","description":"\u003cp\u003eReferences. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126 Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 1 Introduction The developmental steps which lead to the formation of the human perineum seem firmly established (Arey 1965; Hamilton and Mossman1972; Moore and Persaud 1998; Wartenberg 1993; Sadler 1995; Larsen 1997). They form the base for the evaluation of the pathogenesis of a great variety of complicated and often serious malformations which occur in this region. This concept has, however, been challenged by the results of an investigation into the n- mal and abnormal development of the anorectum in pig (van der Putte and Neeteson 1983, 1984; van der Putte 1986). Observations revealed that at least in pig, a major element in current ideas about the early development of the perineum, namely the process by which the original simple cloaca is sub- vided into a urogenital and anal part is incorrect, while additional obser- tions strongly suggested that the same may be true for ideas about female and male sexual transformation. A preliminary investigation in human - bryos gave similar indications (van der Putte 1986). The data supported e- lier critical findings (Politzer 1931, 1932; Wijnen 1964; Ludwig 1965) which have apparently been ignored, possibly because they seemed to hinder the understanding of the pathogenesis of congenital malformations such as - perforate anus and hypospadias.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783540210399\"\u003e\u003ch3\u003eA Comprehensive Histological Study with a Special Reference to the Role of the Stromal Components\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783540210399","offer_id":39427188064349,"sku":"9783540210399","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5b2dc26c-4a71-42b9-a4f6-b554e9e44bcb.jpg?v=1775800361","url":"https:\/\/shop.autorenwelt.de\/products\/the-development-of-the-perineum-in-the-human-a-comprehensive-histological-study-with-a-special-reference-to-the-role-of-the-stromal-components-von-s-c-j-van-der-putte","provider":"Autorenwelt Shop","version":"1.0","type":"link"}