{"product_id":"the-cotransporter-napi-iia-enzyme-dependent-activity-regulation-cellular-mechanisms-and-health-effects-von-miribane-dermaku-sopjani-mentor-sopjani","title":"The cotransporter NaPi-IIa: enzyme-dependent activity regulation","description":"\u003cp\u003eThe sodium-coupled phosphate transporter NaPi-IIa is the main cellular carrier accomplishing kidney phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the basolateral cell membrane through the Na+\/K+ ATPase. Energy starvation is sensed by the AMPK, a serine\/threonine kinase stimulating several cellular mechanisms increasing energy production and limiting energy consumption. AMPK provides a critical link between energy metabolism and cellular transport. The aging suppressor Klotho, a transmembrane protein, is a protease and hormone has been shown to exert a profound effect on phosphate metabolism, aging, and lifespan. Additionally, the enzymes SGK1, mTOR, Akt\/PKB and Nedd4-2 are of critical importance for a wide variety of functions including bone mineralization and energy metabolism. The present book explores the mechanisms of phosphate homeostasis and the role of AMPK, Klotho, SGK1, mTOR, Akt\/PKB and Nedd4-2 in the regulation of NaPi-IIa activity.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786139457779\"\u003e\u003ch3\u003eCellular mechanisms and health effects\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786139457779","offer_id":39459662921821,"sku":"9786139457779","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/962a4650-979d-4d47-97d0-31255332f807.jpg?v=1773123928","url":"https:\/\/shop.autorenwelt.de\/products\/the-cotransporter-napi-iia-enzyme-dependent-activity-regulation-cellular-mechanisms-and-health-effects-von-miribane-dermaku-sopjani-mentor-sopjani","provider":"Autorenwelt Shop","version":"1.0","type":"link"}