{"product_id":"the-ciliopathies-von-jonathan-tobin","title":"The Ciliopathies","description":"\u003cp\u003eThe ciliopathies are a rare class of human genetic disorder caused by  dysfunction of the primary cilium in development and adulthood. This  work investigates several novel elements of these diseases. Using  advanced image analysis, facial dysmorphology in patients with  ciliopathies is characterised and modelled in zebrafish. This uncovers a  new role for ciliopathy proteins in cell migration, and furthermore in  Sonic Hedgehog signalling.  The zebrafish is used to model the renal  component of ciliopathies and a therapeutic assay is developed to test  the efficacy of drugs to treat renal cysts. Together, these findings have  contributed to the diagnosis and potential treatments for ciliopathies.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838341071\"\u003e\u003ch3\u003eA functional and therapeutic investigation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838341071","offer_id":39498908794973,"sku":"9783838341071","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a1ca7f13-8a95-4df5-ba82-97727288fa66.jpg?v=1774760338","url":"https:\/\/shop.autorenwelt.de\/products\/the-ciliopathies-von-jonathan-tobin","provider":"Autorenwelt Shop","version":"1.0","type":"link"}