{"product_id":"techniques-in-prion-research-von-undefined","title":"Techniques in Prion Research","description":"Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin.\nAlthough the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs.\nThis book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods.\n\nFeatures:\nPurification of PrPC and the Pathological Isoform of Prion Protein (PrPsc or PrP-res)\nAnimal Models of TSEs\nCell Culture Models of TSEs\nPrPsc Immunohistochemistry\nWestern Immunoblotting Techniques\nAntibody Production and ELISA\nTSE Strain Typing in Mice\nBiosafety and Decontamination Procedures\nCell-free Conversion of Prion Proteins\nCytotoxicity of PrP Peptides\nCyclic Amplification of Prion Protein Misfolding\u0026lt;\n\nOf interest to:\nResearchers and clinicians in the fields of cell biology, biomedicine, neuroscience\/neuropathology, veterinary medicine and biochemistry.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783764324155\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783764322243\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Hardcover - 9783764324155","offer_id":49692849865029,"sku":"9783764324155","price":181.89,"currency_code":"EUR","in_stock":true},{"title":"Softcover - 9783764322243","offer_id":49592961204549,"sku":"9783764322243","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/68180807-00c6-4dc6-a5c5-a0f47c8b4a07.jpg?v=1753161346","url":"https:\/\/shop.autorenwelt.de\/products\/techniques-in-prion-research-von-undefined","provider":"Autorenwelt Shop","version":"1.0","type":"link"}