{"product_id":"targeting-functional-centers-of-the-ribosome-von-chen-davidovich","title":"Targeting Functional Centers of the Ribosome","description":"\n                \u003cp\u003eThis thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself. \u003c\/p\u003e\n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642267055\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642169304\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783642267055","offer_id":39428472537181,"sku":"9783642267055","price":53.49,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9783642169304","offer_id":40562871631965,"sku":"9783642169304","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/0216e977-7804-40e5-aa80-f9b602241642.jpg?v=1775801988","url":"https:\/\/shop.autorenwelt.de\/products\/targeting-functional-centers-of-the-ribosome-von-chen-davidovich","provider":"Autorenwelt Shop","version":"1.0","type":"link"}