{"product_id":"targeting-exogenous-proteins-to-mitochondria-von-victoria-del-gaizo-moore","title":"Targeting Exogenous Proteins to Mitochondria","description":"\u003cp\u003eDefects in mitochondrial function are responsible for many human diseases. Two major problems have hindered gene therapy of mitochondria defects: 1) Mitochondria are in all tissues of the body so a gene therapy must be capable of reaching all tissues. 2) The therapy must localize specifically to mitochondria. Using a short peptide sequence derived from the HIV genome, called TAT, the hypothesis that TAT fusion proteins could cross both mitochondrial membranes and incorporation of a mitochondrial signal sequence (MTS) into a TAT fusion protein would allow processing and localization of exogenous proteins in mitochondria was tested. Using isolated mitochondria, cultured cells, animals, and model membranes, TAT-MTS proteins rapidly transduces into large unilamellar vesicles, cells and mitochondria, and persisted over time in vitro and in vivo. TAT-MTS fusion proteins will be a useful tool in understanding mitochondrial function as well as the development of mitochondrial protein therapies.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659156304\"\u003e\u003ch3\u003eThe signal and the trap: Using the TAT PTD with a Mitochondrial Targeting Sequence\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659156304","offer_id":39487737036893,"sku":"9783659156304","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/59c77eb6-e79d-401d-bc59-b7d241046b26.jpg?v=1759210478","url":"https:\/\/shop.autorenwelt.de\/products\/targeting-exogenous-proteins-to-mitochondria-von-victoria-del-gaizo-moore","provider":"Autorenwelt Shop","version":"1.0","type":"link"}