{"product_id":"synthesis-of-new-diclofenac-derivatives-von-noor-aldabagh-monther-alameri","title":"Synthesis of New Diclofenac Derivatives","description":"\u003cp\u003eCyclo-oxygenase enzymes are responsible for synthesis of prostaglandins, COX-1 is constitutive and synthesize the prostaglandins that responsible for gastric mucosa protection. While COX-2, is induced during inflammation processes. So; inhibition of COX-2 enzymes, while maintaining the activity of COX-1 enzymes, is the aim of synthesis of newer anti-inflammatory agents. Sulfonamides derivatives, and some heterocyclic rings as 2-amino thiazole,and 2-amino pyridine, will increase the selectivity of compounds toward COX-2 inhibition, rather than COX-1; due to their ability to incorporated in the side pocket that is present in the COX-2 hydrophobic channel, there fore, they are linked with many non selective Anti-inflammatory drugs to modify their selectivity, by that reduce the gastric ulceration associated with inhibition of COX-1 enzyme.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659844300\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659844300","offer_id":39434981146717,"sku":"9783659844300","price":59.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/18ddf4ee-8bae-4e3f-a9de-f3b9e4f07c28.jpg?v=1769238709","url":"https:\/\/shop.autorenwelt.de\/products\/synthesis-of-new-diclofenac-derivatives-von-noor-aldabagh-monther-alameri","provider":"Autorenwelt Shop","version":"1.0","type":"link"}