{"product_id":"synthesis-of-c-glycosides-via-ramberg-backlund-reaction-von-guangli-yang","title":"Synthesis of C-Glycosides via Ramberg-Backlund Reaction","description":"\u003cp\u003eA novel methodology has been described,  employing the Ramberg-Bäcklund rearrangement to  synthesize C-glycosides. The Ramberg-Bäcklund  sequence to provide C-glycosides includes three  intermediates: thioglycoside, sulfonyl glycoside,  and exo-glycal. Thio-glycosides can be easily made  using different methods. Sulfone formation was  routine with MMPP. The one-pot Ramberg-Bäcklund  reaction of sulfone was done using C2Br2F4 , t-BuOH  and KOH\/Al2O3 under reflux to afford an exo-glycal  intermediate. The belta-C-glycosides can be made by  hydrogenolysis of exo-glycals using H2 and Pd\/C. The  alpha-C-glycosides can be made stereoselectively  from exo-glycals via intramolecular ionic  hydrogenation as the key step. Some of the C- glycerolipids that have been prepared exhibit  strikingly similar in vitro antiproliferative  effects to those of O-glycoside analogs.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838358765\"\u003e\u003ch3\u003eSynthesis of C-Glycosides KRN-7000\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838358765","offer_id":39469158924381,"sku":"9783838358765","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/db72ab15-3cd0-4600-b410-48ab43884772.jpg?v=1757742050","url":"https:\/\/shop.autorenwelt.de\/products\/synthesis-of-c-glycosides-via-ramberg-backlund-reaction-von-guangli-yang","provider":"Autorenwelt Shop","version":"1.0","type":"link"}