{"product_id":"synthesis-docking-and-qsar-of-isoxazole-derivatives-von-sahaya-asirvatham","title":"Synthesis, Docking and QSAR of Isoxazole derivatives","description":"\u003cp\u003eA series of newer 3-(4'-methoxyphenyl)-5-substituted phenylisoxazoles derivatives have been synthesized by reacting hydroxylamine hydrochloride with chalcone. The chalcones were formed by reacting different aromatic aldehydes with 4-methoxyacetophenone in presence of aqueos KOH. The acute toxicity study was carried on all the synthesized compounds and they were screened for their anti-inflammatory activity by carrageenan induced paw edema method. Anti-inflammatory studies showed statistically significant activity when compared to control indomethacin. The two most potent compounds giving good anti-inflammatory activity were further evaluated for their anti-ulcer activity. The compounds were subjected to docking and quantitative structure activity relationships (QSAR) studies.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659632990\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659632990","offer_id":39433954459741,"sku":"9783659632990","price":61.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/956e7ca8-8897-4b51-b6ff-28fb0244f62d.jpg?v=1769235040","url":"https:\/\/shop.autorenwelt.de\/products\/synthesis-docking-and-qsar-of-isoxazole-derivatives-von-sahaya-asirvatham","provider":"Autorenwelt Shop","version":"1.0","type":"link"}