{"product_id":"synthesis-biological-investigation-of-fluorinated-amino-acid-analogs-von-ayse-demir","title":"Synthesis \u0026 biological investigation of fluorinated amino acid analogs","description":"\u003cp\u003eIntegrins are cell surface receptors that take part in cell ¿ cell adhesion and cell ¿  extracellular matrix (ECM) adhesion events as well as in cell migration and cell  signaling. ¿5¿1 integrins are expressed on a wide range among brain tumor cells.  In this study, an intermediate spiroisoxazolinopyrrole of the most specific ¿5¿1  integrin antagonist SJ749 was synthesized. Fischer esterification reaction, Swern  oxidation, and Wittig olefination were performed. Next, fluorinated diaminopropionate  molecules were synthesized for coupling to SJ749 instead of the (2,4,6-trimethylphenyl)  diaminopropionate. Finally, the biological evaluation of the molecules synthesized was  performed. These assays included cytotoxicity and cell proliferation.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783847348344\"\u003e\u003ch3\u003eNovel Amino Acid-Based Molecules and Their Fluorinated Derivatives That May Bind Specifically To the ¿5\/¿1 Integrin\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783847348344","offer_id":39493563580509,"sku":"9783847348344","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/2dc3eafb-09dd-4342-b38d-f5a982609c22.jpg?v=1758431106","url":"https:\/\/shop.autorenwelt.de\/products\/synthesis-biological-investigation-of-fluorinated-amino-acid-analogs-von-ayse-demir","provider":"Autorenwelt Shop","version":"1.0","type":"link"}