{"product_id":"sustained-release-tablets-von-akhtar-rasul-tariq-mahmood-und-barkat-ali-khan","title":"SUSTAINED RELEASE TABLETS","description":"\u003cp\u003eThe present study was undertaken to develop oral  sustained release tablets of metoprolol tartrate  using natural hydrophilic matrix formers (xanthan  gum and tragacanth). Sustained release matrix  tablets of metoprolol tartrate were prepared by  using different ratios of drug, xanthan gum and  tragacanth. Microcrystalline cellulose (MCC) was  used as diluent. The polymer was incorporated into a  matrix system using direct compression technique.  Different formulations were evaluated with respect  to dissolution profile in 900 mL phosphate buffer  (pH 6.8), 0.1 M HCl solution and distilled water for  12 h at 37°C. Increasing the amount of polymer  (xanthan gum) in the formulation led to slow release  of drug. The kinetic treatment showed the best  fitted different mathematical models (Zero order,  First order, Higuchiís and Hixson-Crowell). Most of  the solid matrix formulations followed Higuchi or  zero order kinetics. The formulations F1, F2, F3 and  F7, F8, F9 showed maximum linearity. The results  showed that the formulation F9 containing 30%  xanthan gum and 10% gum tragacanth is the most  similar to that of the reference marketed  preparation.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844323719\"\u003e\u003ch3\u003eUse of Natural Gums\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844323719","offer_id":39470103003229,"sku":"9783844323719","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c0f03955-9070-4709-8d03-c5c827e96c34.jpg?v=1769495499","url":"https:\/\/shop.autorenwelt.de\/products\/sustained-release-tablets-von-akhtar-rasul-tariq-mahmood-und-barkat-ali-khan","provider":"Autorenwelt Shop","version":"1.0","type":"link"}