{"product_id":"survey-of-active-pharmaceutical-ingredients-excipient-incompatibility-von-tamilvanan-shunmugaperumal","title":"Survey of active pharmaceutical ingredients-excipient incompatibility","description":"\u003cp\u003eTo improve physico-chemical properties of an active pharmaceutical ingredient (API) at its preformulation stage, myriad of excipients having defined functional roles like solubility enhancement by co-solvent, micells formation and complexation, intestinal permeability enhancement through the inhibition of efflux transport mechanisms, stability-improvement using pH adjustment, cryo-and lyo-protectants, etc are incorporated into a dosage form containing the API. Although considered primarily as inactive materials, the excipient(s) may react with the API resulting in the development of a detrimental or beneficial substance within the API-loaded dosage form itself. If detrimental substances are formed, then, the issue of API-excipient incompatibility will come up and demand the reformulation of the API, which is costly and time-consuming. This book surveys a comprehensive list of published examples of API-excipient incompatibility relevant to currently or previously marketed drugs. With this coverage, this book also provides first-hand information on the multicomponent nature and complexity of the excipients to the formulation scientist.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843364935\"\u003e\u003ch3\u003eNature and mechanism\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843364935","offer_id":39469985661021,"sku":"9783843364935","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/6b787700-4124-4c62-aa65-fd6fe35df15c.jpg?v=1769494225","url":"https:\/\/shop.autorenwelt.de\/products\/survey-of-active-pharmaceutical-ingredients-excipient-incompatibility-von-tamilvanan-shunmugaperumal","provider":"Autorenwelt Shop","version":"1.0","type":"link"}