{"product_id":"study-on-in-vitro-in-vivo-correlation-of-pyridostigmine-bromide-von-yuh-tyng-huang","title":"Study on in vitro\/in vivo correlation of pyridostigmine bromide","description":"\u003cp\u003ePyridostigmine bromide (PB), a highly hygroscopic drug was selected as the model drug. The PB sustained-release (SR) dosage forms that were developed by extrusion-spheronization, direct compression and fluid-bed methods. Produced by the aforementioned methods, the optimal PB-SR dosage forms could improve the hygroscopic defect of PB and reach the SR effect. In vivo study, a good linear regression relationship was observed between the fraction dissolution and fraction absorption for the optimal PB-SR dosage forms. However, the results of microdialysis technique shown that the release of acetylcholine and the release of protein unbound drug for the PB-SR pellets provided with SR effect in vivo as well.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639819106\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783639819106","offer_id":39423441174621,"sku":"9783639819106","price":35.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/20a453f6-7cc9-4f71-880a-e224d64c0599.jpg?v=1776054712","url":"https:\/\/shop.autorenwelt.de\/products\/study-on-in-vitro-in-vivo-correlation-of-pyridostigmine-bromide-von-yuh-tyng-huang","provider":"Autorenwelt Shop","version":"1.0","type":"link"}