{"product_id":"structural-approaches-for-targeted-therapy-the-complex-world-of-tumor-associated-carbohydrate-antigens-in-cancer-von-somdutta-saha","title":"Structural Approaches for Targeted Therapy","description":"\u003cp\u003eTumor associated carbohydrate antigens (TACAs) are a class of glycans with important structural and signaling functions playing a major role in cell proliferation, differentiation, and apoptosis relevant to oncology. Structure-based approaches have been used to study antigen-antibody interactions in the tumor micro-environment and a peptidyl ligand was also designed that mimics the molecular topology of TACAs even though they are chemically dissimilar but functionally equivalent molecular structures. This work on antibody-TACA interactions suggests that in designing antibodies, careful consideration should be made in using mutations that enhance the rigidity of an antibody. This work also suggests that electrostatics play a major role in the recognition of the model antigen examined. Discrimination against wanted targets through repulsive electrostatic interactions might be more fruitful than a strong optimization of target binding. Increased specificity toward one target leads to decreased affinity towad others.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659949296\"\u003e\u003ch3\u003eThe complex world of tumor associated carbohydrate antigens in cancer\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659949296","offer_id":39435167465565,"sku":"9783659949296","price":49.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/0acc7d93-28d2-45bf-9da8-4b85686ef576.jpg?v=1773382617","url":"https:\/\/shop.autorenwelt.de\/products\/structural-approaches-for-targeted-therapy-the-complex-world-of-tumor-associated-carbohydrate-antigens-in-cancer-von-somdutta-saha","provider":"Autorenwelt Shop","version":"1.0","type":"link"}