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By late 2009, Nigeria remained the only polio endemic country in Africa and one of the only four in the world.Polio cases rose astronomically between 2003 and 2009, a period that coincided with immunization boycott in Northern Nigeria.Global polio eradication partners, led by UNICEF adopted a new communication approach that led to 99% drop in polio cases between 2009 and 2010. This work reveals a strong link between the application of UNICEF- developed ACADA model for communication planning and the positive response of mothers to polio eradication campaign. Development communication scholars and development agencies will find this work very useful.