{"product_id":"stem-cell-and-growth-factor-delivery-vehicles-for-cartilage-repair-von-abby-sukarto","title":"Stem cell and growth factor delivery vehicles for cartilage repair","description":"\u003cp\u003eCo-delivery of embedded growth factor-loaded microspheres and adult stem cells in a hydrogel matrix was studied for its potential as a cell-based therapeutic strategy for cartilage regeneration in partial thickness chondral defects. A photopolymerizable N-methacrylate glycol chitosan (MGC) was employed to form an in situ gel that was embedded with two formulations of growth factor-loaded microspheres and human adipose-derived stem cells (ASC). The polymeric microspheres were used as a delivery vehicle for the controlled release of growth factors to stimulate differentiation of the ASC towards the chondrocyte lineage. Bone morphogenetic protein-6 (BMP-6) and transforming growth factor-b3 (TGF-b3) were delivered at 5 ng\/day at highly bioactive states. The ratio of collagen type II to I per cell was significantly higher for ASC chondrogenesis induced by the sustained release of BMP-6 and TGF-b3 in MGC gels than that of non-induced ASC or with soluble growth factor administration in the culture media. Thus, the co-delivery of growth factor-loaded microspheres and ASC in MGC gels successfully induced ASC chondrogenesis and is a promising strategy for cartilage repair.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659229817\"\u003e\u003ch3\u003eCo-delivery of growth factor-loaded microspheres and human adipose stem cells in a gel matrix for cartilage repair\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659229817","offer_id":39486429134941,"sku":"9783659229817","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/aa611827-dc9b-474a-98d7-509b5b01f856.jpg?v=1774758631","url":"https:\/\/shop.autorenwelt.de\/products\/stem-cell-and-growth-factor-delivery-vehicles-for-cartilage-repair-von-abby-sukarto","provider":"Autorenwelt Shop","version":"1.0","type":"link"}