{"product_id":"ss-catenin-tcf-and-icat-von-mohammad-zulfiquer-hossain","title":"¿-Catenin, TCF, and ICAT","description":"\u003cp\u003eIn addition to working together to drive expression of target genes, ¿-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood.  To study the specific role of ¿-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ¿-catenin-TCF interactions, in the T cell lineage. We found that ¿-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ¿-catenin-TCF interactions in normal thymic involution. We also discovered that ¿-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ¿-catenin. This study, thus, provides novel insights into the role of ¿-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838334509\"\u003e\u003ch3\u003eNovel Roles in T Cell Development, Function, and Aging\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838334509","offer_id":39498951852125,"sku":"9783838334509","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/32e1ecc3-79f9-4556-9066-187b6660db91.jpg?v=1757741815","url":"https:\/\/shop.autorenwelt.de\/products\/ss-catenin-tcf-and-icat-von-mohammad-zulfiquer-hossain","provider":"Autorenwelt Shop","version":"1.0","type":"link"}