{"product_id":"splicing-and-inflammatory-factors-in-cancer-survival-and-therapy-von-adeeb-shehzad","title":"Splicing And Inflammatory Factors In Cancer Survival And Therapy","description":"\u003cp\u003eThis book underpins the Prp4 and PGE2-induced cancer cell's survival and underlying mechanism of anti-cancer and radiosensitizing effects of curcumin (a derivative of turmeric) in colorectal carcinoma as well as in B16F10-induced tumor xenograft. Curcumin and ionizing radiation (IR) inhibited HCT-15 cell proliferation, induced apoptosis, and reduced tumor volume in C57BL6\/J mice. Transfection of HCT-15 cells with splicing factor Prp4 clone reverses curcumin and IR-induced cell death. However, knockdown of Prp4 with siRNA diminished the protective effects of Prp4 against curcumin and IR-induced apoptosis in HCT-15 cells. Curcumin treatment also restored the IR-induced cell death as well as greatly reduced the tumor volume by regulating the level of antioxidant enzymes. PGE2, an inflammatory mediator, inhibited curcumin-induced oxidative stress apoptosis by regulating survival pathways such as COX-2 and PKA, Ras\/Raf\/Erk, and NF-¿B through EP2 receptor. Taken together, splicing factor Prp4 and inflammatory mediator PGE2 enhances the survival as well as protect the cancer cells death by activating the anti-oxidant enzymes, Ras\/Raf\/Erk, and NF-¿B pathways.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202669702\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786202669702","offer_id":39465842081885,"sku":"9786202669702","price":61.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/2d19385a-c1a0-47df-b62d-649f32635081.jpg?v=1770705578","url":"https:\/\/shop.autorenwelt.de\/products\/splicing-and-inflammatory-factors-in-cancer-survival-and-therapy-von-adeeb-shehzad","provider":"Autorenwelt Shop","version":"1.0","type":"link"}