{"product_id":"specifichnost-i-struktura-v-kletok-pri-perwichnom-sindrome-sogrena-von-lara-a-akrawi","title":"Specifichnost' i struktura V-kletok pri perwichnom sindrome S'ögrena","description":"\u003cp\u003eSindrom S'ögrena (SS) - äto hronicheskoe autoimmunnoe zabolewanie, harakterizuüscheesq ochagowym wospaleniem slünnyh i sleznyh zhelez, chto priwodit k takim rasprostranennym simptomam, kak suhost' glaz i suhost' wo rtu. Zdes' mononuklearnye kletki, wklüchaq V-kletki, infil'triruüt zhelezy, chto priwodit k ih disfunkcii i posleduüschemu razrusheniü. Esche odnoj otlichitel'noj osobennost'ü qwlqetsq sistemnaq wyrabotka autoantitel, kotoraq proishodit w rezul'tate aktiwacii V-kletok w plazmaticheskie kletki, sekretiruüschie antitela. Takim obrazom, hotq ätiologiq SS ostaetsq neqsnoj, V-kletki igraüt wazhnuü rol' w patogeneze ätogo zabolewaniq. V ätoj doktorskoj rabote my issleduem immunologicheskij process, rassmatriwaq koncepciü specifichnosti i patterna V-kletok pri perwichnom SS (pSS). My rassmatriwaem kak obschij, tak i autoantigen-specificheskij pattern V-kletok w perifericheskoj krowi i slünnyh zhelezah pacientow s PSS, a takzhe uchitywaem pattern äxpressii autoantigena Ro52. Krome togo, my issleduem wrozhdennyj shtamm myshej NOD, a imenno NOD.B10.H2b, chtoby oharakterizowat' otdelenie plazmaticheskih kletok w okoloushnoj i podchelüstnoj slünnyh zhelezah i w kostnom mozge.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786208550868\"\u003e\u003ch3\u003eIssledowaniq na lüdqh i myshinoj modeli\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786208550868","offer_id":53966109278533,"sku":"9786208550868","price":59.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a1db574b-e189-4bb9-8875-182f9d2585be.jpg?v=1749962540","url":"https:\/\/shop.autorenwelt.de\/products\/specifichnost-i-struktura-v-kletok-pri-perwichnom-sindrome-sogrena-von-lara-a-akrawi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}