{"product_id":"sostaw-i-razrabotka-lamotridzhina-dispergiruemyh-wo-rtu-w-tabletkah-von-rumit-shah-und-bhumit-patel","title":"Sostaw i razrabotka lamotridzhina, dispergiruemyh wo rtu w tabletkah","description":"\u003cp\u003eLamotridzhin otnositsq k kategorii protiwoäpilepticheskih preparatow. Jeto preparat klassa II po klassifikacii BCS, nerastworimyj w wode, period poluraspada sostawlqet 24-25 chasow s biodostupnost'ü 90%. Dlq polucheniq powyshennoj skorosti rastworeniq lamotridzhina in-vitro s pomosch'ü metoda Liquisolid tabletki Liquisolid byli optimizirowany s pomosch'ü QbD-DoE podhoda 32 polnogo faktorial'nogo dizajna s ispol'zowaniem programmnogo obespecheniq Design Expert. Vse prigotowlennye partii likisolida byli podwergnuty ispytaniqm na izmenenie wesa, odnorodnost' soderzhaniq lekarstwennogo weschestwa, twerdost', test na ryhlost', test na dezintegraciü i test na rastworenie. Likwisolidnye sistemy takzhe byli protestirowany na DSK, IK-Fur'e. Po rezul'tatam analiza raschetnyh dannyh w kontrol'noj tochke, LMLCODT1 pokazywaet bolee wysokoe wyswobozhdenie preparata pri men'shem wremeni smachiwaniq i wremeni raspada (5,24 sek), chto powyshaet rastworimost' lamotridzhina na 4,73 mg\/ml. Takim obrazom, dannaq issledowatel'skaq rabota mozhet byt' polezna dlq razrabotki receptury orodispergiruemyh tabletok s ispol'zowaniem tehniki Liquisolid, kotoraq mozhet obespechit' bystroe nachalo dejstwiq za schet bystrogo wsasywaniq, maximal'nuü äffektiwnost', snizhenie dozy i chastoty priema i, sledowatel'no, powyshenie komplaentnosti pacientow.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786205823743\"\u003e\u003ch3\u003eZhidkaq tehnologiq\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786205823743","offer_id":46438974587205,"sku":"9786205823743","price":28.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c577ce8e-50a9-44cc-b232-f2f677f0a1df.jpg?v=1758950023","url":"https:\/\/shop.autorenwelt.de\/products\/sostaw-i-razrabotka-lamotridzhina-dispergiruemyh-wo-rtu-w-tabletkah-von-rumit-shah-und-bhumit-patel","provider":"Autorenwelt Shop","version":"1.0","type":"link"}