Cyclorins, hydrophilic carriers, are cyclic polysaccharides which have property of forming inclusion complex with various guest molecules with suitable polarity and dimensions. They have been used extensively for solubility enhancement of hydrophobic drug/water insoluble drugs. Diacerein is anthraquinone compound designed to treatment of osteoarthritis. The purpose of this research was to enhance the solubility and therefore dissolution of Diacerein by complexation with ß-cyclodextrin (ßCD) and hydroxyl propyl ß-cyclodextrin (HP ßCD).This study represents the formulation of inclusion complex with ßCD and HP ßCD by kneading method and their characterization and evaluation of improvement in dissolution profile. Inclusion complex compared to pure drug and physical mixtures, remarkable enhancement in invitro drug release profile in PH 6.8 phosphate buffer was obtained in both inclusion complexes of ßCD and HP ßCD, especially with HP ßCD. Complexation of Diacerein with hydrophilic carriers like ßCD and HP ßCD offers a major enhancement in drug solubility.
Tags: Medizin, Pharmazie
Taschenbuch - 9783848486458 Verlag: LAP Lambert Academic Publishing Ersterscheinung: April 2012 ISBN-13: 9783848486458 Größe: 220 mm x 150 mm x 5 mm Gewicht: 142 Gramm 84 Seiten Versandfertig in 3-5 Tagen.