Solubility enhancement of diacerin using cyclodextrin: Solubility and evalution of diacerein using cyclodextrin as hydrophillic carriers

Solubility enhancement of diacerin using cyclodextrin: Solubility and evalution of diacerein using cyclodextrin as hydrophillic carriers


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von Prasad Patrekar, Vishal Dalvi, Chandrakant Patil

Beschreibung

Cyclorins, hydrophilic carriers, are cyclic polysaccharides which have property of forming inclusion complex with various guest molecules with suitable polarity and dimensions. They have been used extensively for solubility enhancement of hydrophobic drug/water insoluble drugs. Diacerein is anthraquinone compound designed to treatment of osteoarthritis. The purpose of this research was to enhance the solubility and therefore dissolution of Diacerein by complexation with ß-cyclodextrin (ßCD) and hydroxyl propyl ß-cyclodextrin (HP ßCD).This study represents the formulation of inclusion complex with ßCD and HP ßCD by kneading method and their characterization and evaluation of improvement in dissolution profile. Inclusion complex compared to pure drug and physical mixtures, remarkable enhancement in invitro drug release profile in PH 6.8 phosphate buffer was obtained in both inclusion complexes of ßCD and HP ßCD, especially with HP ßCD. Complexation of Diacerein with hydrophilic carriers like ßCD and HP ßCD offers a major enhancement in drug solubility.


Tags: Medizin, Pharmazie


Taschenbuch - 9783848486458
Verlag: LAP Lambert Academic Publishing
Ersterscheinung: April 2012
ISBN-13: 9783848486458
Größe: 220 mm x 150 mm x 5 mm
Gewicht: 142 Gramm
84 Seiten
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