{"product_id":"solubility-enhancement-development-of-extended-release-matrix-pellets-of-water-insoluble-azilsartan-medoxomil-using-with-its-solid-dispersion-von-vishal-sanklecha-vishal-pande","title":"Solubility Enhancement","description":"\u003cp\u003eThe present study involved the design \u0026amp; development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD \u0026amp; the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology \u0026amp; swelling behaviour \u0026amp; analysis carried out using FTIR, DSC \u0026amp; powder XRD. The solubility \u0026amp; dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility \u0026amp; dissolution of azilsartain medoxomil by using polycarbophil \u0026amp; HPMC K4M, forming an effective carrierfor developing extended release matrix pellets.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786200471789\"\u003e\u003ch3\u003eDevelopment of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786200471789","offer_id":39464744976477,"sku":"9786200471789","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/cece7d4d-fae0-4d78-a38b-7b8a10f30677.jpg?v=1758001539","url":"https:\/\/shop.autorenwelt.de\/products\/solubility-enhancement-development-of-extended-release-matrix-pellets-of-water-insoluble-azilsartan-medoxomil-using-with-its-solid-dispersion-von-vishal-sanklecha-vishal-pande","provider":"Autorenwelt Shop","version":"1.0","type":"link"}