{"product_id":"small-non-coding-rnas-in-prokaryotes-von-christian-g-ramos-andre-m-grilo-und-jorge-h-leitao","title":"Small non-coding RNAs in Prokaryotes","description":"\u003cp\u003eMore than 140 bacterial small non-coding RNAs  (sRNAs) have been discovered in Escherichia coli and  other bacteria, most of them pathogenic. The sRNA  genes are typically encoded in intergenic regions  and range from 50 to 500 nucleotides long. Evidences  accumulated over the last years point out that sRNAs  act as major regulators of adaptive responses at the  post-transcriptional level. The mechanisms by which  sRNAs modulate the expression of its targets often  involve the interaction with their mRNA targets,  mediated by the Hfq protein a RNA chaperone. The RNA  chaperone Hfq, has been shown to play  multiple roles in the biology of bacteria, acting as  a pleiotropic regulator. In recent years, the vast  majority of sRNAs have  been identified by bioinformatics, as is the case of  the 213 putative sRNA genes in B. cenocepacia J2315.  Preliminary identification and target prediction of  Hfq-dependent sRNAs raise interesting questions. The  roles played by sRNAs in gene regulation, their  interdependence of Hfq and their potential as  suitable targets for the development of new  antimicrobials is presented and discussed.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838321165\"\u003e\u003ch3\u003eRoles in Pathogenesis and Potential Therapeutic Targets\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838321165","offer_id":39498966827101,"sku":"9783838321165","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/6b80e99d-aaa1-4eda-a040-83426f824ecf.jpg?v=1773385039","url":"https:\/\/shop.autorenwelt.de\/products\/small-non-coding-rnas-in-prokaryotes-von-christian-g-ramos-andre-m-grilo-und-jorge-h-leitao","provider":"Autorenwelt Shop","version":"1.0","type":"link"}