{"product_id":"sjogrens-syndrome-clinical-and-immunological-aspects-von-stuart-s-kassan-haralampos-m-moutsopoulos-norman-talal-hrsg","title":"Sjögren’s Syndrome","description":"\u003cp\u003eI have been a student of Sjogren's syndrome for virtually all of my professional life. My education in this disease began in 1962 when I arrived at the National Institutes of Health to begin a Clinical Asso­ ciateship with Dr. Joseph J. Bunim. Bunim introduced me to a pat­ ient with Sjogren's syndrome of 8 years duration who had devel­ oped malignant lymphoma 6 months previously. He told me that there were other such patients. I obtained serum samples from these patients and studied them by the then new technique of immuno­ electrophoresis. We observed that an initial hypergammaglobulin­ emia could progressively decline to hypogammaglobulinemia with loss of autoantibodies. One patient in this initial series had macrog­ lobulinemia. We published this report and suggested that the auto­ immunity predisposed to the malignant transformation. Thus began my love affair with this disease. In those days many rheumatologists considered Sjogren's syn­ drome simply a variant of rheumatoid arthritis. It's curious that two decades ago there was little confusion between Sjogren's syndrome and systemic lupus erythematosus, whereas today there is great con­ fusion. There is still a great need for internationally agreed upon di­ agnostic criteria, which merely illustrates once again the difficulty of accurate diagnosis in our profession. The multidisciplinary aspects of Sjogren's syndrome require au­ thorities in several areas of medicine. The various chapter contribu­ tors are experts in their field and have often put aside other respon­ sibilities to complete their contributions and not delay publication.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642501203\"\u003e\u003ch3\u003eClinical and Immunological Aspects\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783642501203","offer_id":39426460319837,"sku":"9783642501203","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4347b5e4-46c1-4a64-985b-3ee43cea5d1f.jpg?v=1755926362","url":"https:\/\/shop.autorenwelt.de\/products\/sjogrens-syndrome-clinical-and-immunological-aspects-von-stuart-s-kassan-haralampos-m-moutsopoulos-norman-talal-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}