{"product_id":"sintez-geterociklow-i-ih-biologicheskaq-ocenka-von-haresh-b-patel","title":"Sintez geterociklow i ih biologicheskaq ocenka","description":"\u003cp\u003eNowaq seriq proizwodnyh (bis)benzotiazol-pirazolilpirazolina byla sintezirowana w odin ätap putem kondensacii sootwetstwuüschim obrazom zameschennyh halkonow, gidrazinobenzotiazolow i NaOH pri ul'trazwukowom metode. Vse wnow' sintezirowannye soedineniq byli issledowany na protiwotuberkuleznuü i protiwomalqrijnuü aktiwnost'. Sredi nih soedineniq 6a (MIC = 62,5 mkg\/ml), 6e (MIC = 25 mkg\/ml), 6f (MIC = 25 mkg\/ml), 6g (MIC = 12,5 mkg\/ml) i 6h (MIC = 12,5 mkg\/ml) pokazali horoshuü ili otlichnuü aktiwnost' po srawneniü s rifampicinom (MIC = 40 mkg\/ml) protiw M. tuberculosis. In vitro protiw P. falciparum soedineniq 6e (IC50 = 0,076 mkg\/ml), 6f (IC50 = 0,098 mkg\/ml) i 6g (IC50 = 0,085 mkg\/ml) proqwili samuü wysokuü protiwomalqrijnuü aktiwnost', a soedineniq 5e, 5g, 6a i 6h pokazali horoshuü aktiwnost' po srawneniü s hininom (IC50 = 0,268 mkg\/ml). Dlq izucheniq citotoxicheskih swojstw sintezirowannyh soedinenij in vitro byla prowedena bioproba s rassol'nymi krewetkami. Jeti rezul'taty pokazywaüt, chto sintezirowannye soedineniq mogut priwesti k razrabotke nowyh moschnyh protiwotuberkuleznyh i protiwomalqrijnyh sredstw. Jeta kniga polezna dlq issledowatelej i predstawitelej akademicheskih krugow, rabotaüschih w ätoj oblasti.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786204910055\"\u003e\u003ch3\u003eSintez (bis)benzotiazol-pirazolilpirazolinow s pomosch'ü ul'trazwuka i biologicheskij skrining\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786204910055","offer_id":40248754765917,"sku":"9786204910055","price":19.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/452c6654-66ba-4f57-b97c-8114b890fb27.png?v=1758348447","url":"https:\/\/shop.autorenwelt.de\/products\/sintez-geterociklow-i-ih-biologicheskaq-ocenka-von-haresh-b-patel","provider":"Autorenwelt Shop","version":"1.0","type":"link"}