{"product_id":"serum-micrornas-as-biomarker-for-active-and-latent-tb-infection-von-grace-wynn-mwangoka","title":"Serum microRNAs as Biomarker for Active and Latent TB Infection","description":"\u003cp\u003eExpression patterns of microRNAs in body fluids can be used as non-invasive rapid and accurate biomarkers for various diseases. The study aimed to identify patterns of microRNA signatures for diagnosis of TB and assess significance of a patient¿s genetic background on signature composition and diagnostic performance. The consented participant with; active tuberculosis, active TB co-infected with HIV, latent TB infection, other pulmonary infection and healthy individuals were enrolled from Italy and East Africa. A signature of 15 miRNAs was observe to differentiate healthy individuals from those with PTB with a diagnostic accuracy of 82% in the RVM and 77% in the logistic classification model. The analysis based on genetic background identified a signature of 10 miRNAs that was specific for the European with a diagnostic accuracy of 83% in RVM, and 81% in the logistic model. Whereas a signature of 12 miRNAs was specific to the African cohort and the diagnostic accuracy increased up to 95% and 100% in RVM and logistic model, respectively.miRNAs are a promising diagnostic candidate for TB, therefore further prospective evaluation of this diagnostic seems warranted to scientist.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786138390282\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786138390282","offer_id":39454818566237,"sku":"9786138390282","price":28.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4d0c0aa0-9638-4b20-aa34-65c78e4a40b3.jpg?v=1773731409","url":"https:\/\/shop.autorenwelt.de\/products\/serum-micrornas-as-biomarker-for-active-and-latent-tb-infection-von-grace-wynn-mwangoka","provider":"Autorenwelt Shop","version":"1.0","type":"link"}