{"product_id":"self-assembly-and-chemo-ligation-of-polymeric-responsive-microgels-von-zhiyong-meng","title":"SELF-ASSEMBLY AND CHEMO-LIGATION OF POLYMERIC RESPONSIVE MICROGELS","description":"\u003cp\u003eMicrogels are sub-micron to micron-size polymeric networks confined in limited space swollen by a good solvent, also called hydrogel microparticles or microspheres if swollen in water. Among all microgels investigated nowadays, poly(N-isopropylacrylamide), pNIPAm, microgels are one of the most extensively studied microgel particles due to their volume phase transition (VPT) at lower critical solution temperature (LCST). By incorporation of pH-responsive monomer, acrylic acid (AAc), copolymeric pNIPAm-AAc microgels further demonstrate multi-responsivity to temperature, pH, and ionic strength. A temperature-programmed polymerization protocol is proposed for the synthesis of large pNIPAm-AAc microgel particles with a hydrodynamic diameter of 2~5 ¿m. Futhermore, to observe the phase behavior of pNIPAm-AAc microgel dispersions, pNIPAm-AAc dispersions at various pH values and concentrations were allowed to age and undergo phase transition in closed system. Finally, the Cu(I)-catalyzed azide-terminal alkyne 1,3-dipolar cycloaddition, also called Sharpless-Meldal ¿click¿ reaction, is used to functionalize pNIPAm-AAc microgel particles for microgel bioconjugation and medical applications.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838387109\"\u003e\u003ch3\u003ePhase Behavior and Click Chemistry of Multi-Responsive Polymeric Microgel Dispersions\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838387109","offer_id":39469238190173,"sku":"9783838387109","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/def8012f-eef7-4345-8119-d516e133502c.jpg?v=1757568167","url":"https:\/\/shop.autorenwelt.de\/products\/self-assembly-and-chemo-ligation-of-polymeric-responsive-microgels-von-zhiyong-meng","provider":"Autorenwelt Shop","version":"1.0","type":"link"}