{"product_id":"role-of-rage-as-an-amphoterin-receptor-from-development-to-disease-von-henri-huttunen","title":"ROLE OF RAGE AS AN AMPHOTERIN RECEPTOR: FROM DEVELOPMENT TO DISEASE","description":"\u003cp\u003eCell migration plays a vital role in many physiological processes,  such as embryonic development and immunological defense, but  also in pathological processes, such as tumor cell invasion.   Amphoterin, also known as High-Mobility Group-Box protein 1  (HMGB1), is highly expressed in immature and malignant cells.  Although it lacks a classical secretion signal, amphoterin is released  from cells to regulate neurite outgrowth, cell migration and  differentiation. Many extracellular functions of amphoterin are  mediated by one of its cell surface receptors Receptor for Advanced  Glycation End products (RAGE), a multiligand receptor belonging to  the immunoglobulin superfamily. This thesis concentrates on  identifying molecular mechanisms through which RAGE mediates  effects of extracellular amphoterin on cells. The results suggest that  amphoterin and RAGE serve as a ligand-receptor pair having  important roles in the regulation of neuronal process growth,  survival and differentiation, and in the regulation of tumor cell  invasiveness.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838323473\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838323473","offer_id":39499059724381,"sku":"9783838323473","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9711aa42-41cd-40b0-8916-46d60167f292.jpg?v=1759296190","url":"https:\/\/shop.autorenwelt.de\/products\/role-of-rage-as-an-amphoterin-receptor-from-development-to-disease-von-henri-huttunen","provider":"Autorenwelt Shop","version":"1.0","type":"link"}