{"product_id":"role-of-neuronal-igf-1r-signaling-in-alzheimers-disease-involvement-in-development-and-progression-von-moritz-m-hettich","title":"Role of neuronal IGF-1R signaling in Alzheimer's disease","description":"\u003cp\u003eBrains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R deficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced A¿ accumulation. In addition A¿ plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced A¿ accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer¿s disease is most likely a compensatory phenomenon.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838128788\"\u003e\u003ch3\u003eInvolvement in development and progression\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783838128788","offer_id":39440641196125,"sku":"9783838128788","price":53.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/03099d9c-9344-4414-b9fe-103cf56f347d.jpg?v=1776315106","url":"https:\/\/shop.autorenwelt.de\/products\/role-of-neuronal-igf-1r-signaling-in-alzheimers-disease-involvement-in-development-and-progression-von-moritz-m-hettich","provider":"Autorenwelt Shop","version":"1.0","type":"link"}