Role of apoptosis in neuroinflammation: Apoptosis Inhibition Can Be Threatening in Aß-induced Neuroinflammation, Through Promoting Cell Proliferation

Role of apoptosis in neuroinflammation: Apoptosis Inhibition Can Be Threatening in Aß-induced Neuroinflammation, Through Promoting Cell Proliferation

von Azadeh Abdi
Taschenbuch - 9783659223365
49,00 €
  • Versandkostenfrei
  • Hinweis: Print on Demand. Lieferbar innerhalb von 7 bis 10 Tagen
  • inkl. MwSt. & Versandkosten (innerhalb Deutschlands)
  • Hinweis: Print on Demand. Lieferbar innerhalb von 7 bis 10 Tagen
  • inkl. MwSt. & Versandkosten (innerhalb Deutschlands)

Autorenfreundlich Bücher kaufen?!

Beschreibung

Beta Amyloid peptide (Aß), specifically Aß (1-42) is toxic to neurons and is hence strongly associated with loss of brain function through the course of Alzheimer's disease. This deposition induces neuronal death and apoptosis. Extensive studies in recent years have focused on Aß-mediated microglia activation with regard to secretion of pro inflammatory cytokines such as TNF-a. TNF-a induces two distinct pathways: one of them is apoptosis and the other one is NF-¿B activation and eventually cell survival and proliferation.One of the questions that came to us was whether there is any relationship between these two path ways and blocking one pathway results in boosting the other one. To probe this issue, we blocked apoptosis and measure NF-¿B activation. Another question arose as the role of apoptosis in neuroinflammation. Whether apoptosis is a protective or destructive mechanism? To achieve this goal, we inhibited apoptosis and evaluated some intracellular changes such as: c-Myc as a proto-oncogene, Hsp70 as a hallmark of cancer that is up regulated by stress and toxins and p53 as a tumor suppressor protein.

Details

Verlag LAP Lambert Academic Publishing
Ersterscheinung September 2012
Maße 220 mm x 150 mm x 5 mm
Gewicht 136 Gramm
Format Taschenbuch
ISBN-13 9783659223365
Auflage Nicht bekannt
Seiten 80

Schlagwörter