{"product_id":"rna-interference-an-antiviral-therapy-for-white-spot-syndrome-virus-von-sarathi-mani","title":"RNA interference: An antiviral therapy for White spot syndrome virus","description":"\u003cp\u003eWhite spot syndrome virus (WSSV) is the causative  agent of white spot disease and is responsible for  severe economic losses in shrimp culture industry  worldwide. Outbreaks of this disease have wiped out  entire populations of shrimp farm within 3-4 days.  WSSV is at present the largest animal virus,  which is a member of the genus Whispovirus within a  new virus family called Nimaviridae. RNA  interference  has recently emerged as a powerful tool for specific  gene silencing in antiviral therapy. The present  study discusses the potential of bacterially  synthesized long dsRNA to silence WSSV structural  genes. The results showed that the degree of  protection afforded by specific dsRNAs varies  between  different viral genes targeted. The significant  survival in shrimp treated with VP28dsRNA confirms  the significant role of VP28 protein in initiating  the WSSV infection in shrimp. We expect that  VP28dsRNA will be desirable to ensure greater  efficacy to protect shrimp from WSSV infection.  Furthermore, an attempt was made to explore the  possibility of protecting shrimp against WSSV  infection using RNAi technology by oral  administration of bacterially expressed VP28dsRNA.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838365510\"\u003e\u003ch3\u003eAn update\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838365510","offer_id":39486532386909,"sku":"9783838365510","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/62d6eecf-aec5-446a-9b9b-ed44aab91bee.jpg?v=1774936231","url":"https:\/\/shop.autorenwelt.de\/products\/rna-interference-an-antiviral-therapy-for-white-spot-syndrome-virus-von-sarathi-mani","provider":"Autorenwelt Shop","version":"1.0","type":"link"}