{"product_id":"risedronate-effects-on-bone-metastasis-of-rat-mammary-tumor-cell-lines-von-kelli-boyd-gregory-hall-und-elizabeth-howerth","title":"Risedronate Effects on Bone Metastasis of Rat Mammary Tumor Cell Lines","description":"\u003cp\u003eWhen compared to MTA cells, MTB-01 cells were susceptible to risedronateinduced  apoptosis, had decreased ability to bind to risedronate-treated bone, and did not  produce MMP-2 or MMP-9 proteases. MTA cells were less susceptible to risedronateinduced  apoptosis and produced MMP-2. Additionally, adhesion of MTA cells to bone  matrix was not diminished by risedronate treatment. Our results suggest that the nonresponsive  nature of the MTA cell line may be due to MMP-2 production (possibly  allowing ongoing destruction of risedronate-treated bone), continued adhesion to  risedronate-treated bone matrix, and decreased susceptibility to risedronate-induced  apoptosis.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783847341529\"\u003e\u003ch3\u003eComparison of  Effects of Risedronate on Bone Metastasis of Two Malignant Rat  Mammary Tumor Cell Lines, MTA \u0026amp; MTB-01\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783847341529","offer_id":39493536874589,"sku":"9783847341529","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/2745e5e2-1684-4572-9a8b-89039efe7cff.jpg?v=1769495178","url":"https:\/\/shop.autorenwelt.de\/products\/risedronate-effects-on-bone-metastasis-of-rat-mammary-tumor-cell-lines-von-kelli-boyd-gregory-hall-und-elizabeth-howerth","provider":"Autorenwelt Shop","version":"1.0","type":"link"}