{"product_id":"retrovirus-restriction-in-primates-and-the-discovery-of-trimcyp-von-david-sayah","title":"Retrovirus Restriction in Primates and the Discovery of TRIMCyp","description":"\u003cp\u003eCells derived from numerous primate species are known to resist HIV-1 infection, a finding that had limited the development of non-human primate models of AIDS.  In recent years, several studies suggested that many primate-derived cell lines possess dominant factors that block infection by various retroviruses.  In the work described here, one of these factors was identified as a protein named TRIM-Cyp.  In addition to its potent ability to interfere with HIV infection, TRIM-Cyp also represents an important mechanism in the formation of new genes - it is a hybrid between two unrelated genes, created by the activity of a retrotransposon.  TRIM-Cyp, and other TRIM5 proteins in various primates, are important determinants of retrovirus tropism, and reveal a great deal about the evolutionary arms race between retroviruses and their hosts.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783836471077\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783836471077","offer_id":39446352527453,"sku":"9783836471077","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/bc3889ce-0548-4da7-a56b-270779e5d2f3.jpg?v=1773209612","url":"https:\/\/shop.autorenwelt.de\/products\/retrovirus-restriction-in-primates-and-the-discovery-of-trimcyp-von-david-sayah","provider":"Autorenwelt Shop","version":"1.0","type":"link"}