{"product_id":"regulqciq-razwitiq-v-kletok-receptorami-antigenow-von-yannek-hauzer","title":"Regulqciq razwitiq V-kletok receptorami antigenow","description":"\u003cp\u003eE-belok E2A horosho izwesten swoimi mnogochislennymi rolqmi wo wremq razwitiq V-kletok. Signalizaciq antigennogo receptora, kotoraq priwodit k ingibirowaniü E2A kal'cij-sensornym belkom kal'modulinom (CaM), imeet ochen' shirokoe znachenie. Bylo pokazano, chto snizhenie regulqcii surrogatnyh legkih cepej receptora pre-V-kletok, a takzhe ko-receptora CD19 proishodit cherez ingibirowanie E2A s pomosch'ü CaM. Bolee togo, neskol'ko komponentow mehanizma rekombinacii Ig, wklüchaq RAG1 i RAG2, ponizhaütsq w rezul'tate ätogo mehanizma, i bylo pokazano, chto komplex rekombinacii wklüchaet RAGs, Pax5 i E2A, kotorye mogut neposredstwenno wyswobozhdat'sq iz lokusa tqzheloj cepi Ig pod dejstwiem signala pre-V-kletochnogo receptora cherez CaM dlq dostizheniq allel'nogo isklücheniq. Zhestkaq regulqciq fermenta diwersifikacii antitel AID takzhe zawisit ot ingibirowaniq E2A s pomosch'ü CaM, i bylo pokazano, chto regulqciq otricatel'noj obratnoj swqzi belkow receptorow pre-V i V-kletok, ko-receptorow i belkow w signal'nyh putqh ot receptora takzhe proishodit cherez ingibirowanie E2A s pomosch'ü CaM. Differencirowka plazmaticheskih kletok induciruetsq ochen' bystrymi regulqtornymi sobytiqmi, kotorye, kak bylo pokazano, zawisqt ot ingibirowaniq E2A CaM.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786204829036\"\u003e\u003ch3\u003eIssledowaniq fiziologicheskoj roli faktorow transkripcii E2A i ih ingibirowaniq kal'modulinom w razwitii V-kletok\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786204829036","offer_id":40165036392541,"sku":"9786204829036","price":19.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/32283966-c804-4fba-a3ef-173c8e6bf2f2.png?v=1759296221","url":"https:\/\/shop.autorenwelt.de\/products\/regulqciq-razwitiq-v-kletok-receptorami-antigenow-von-yannek-hauzer","provider":"Autorenwelt Shop","version":"1.0","type":"link"}